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Metastatic retinoblastoma of the maxilla and mandible

¹ Department of Oral and Maxillofacial Radiology, Hiroshima University Hospital, Hiroshima, Japan; ² Center of Oral Clinical Examination, Hiroshima University Hospital, Hiroshima, Japan; ³ Department of Oral and Maxillofacial Radiology, Division of Medical Intelligence and Informatics, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

*Correspondence to: Akira Taguchi, DDS, PhD, Department of Oral and Maxillofacial Radiology, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan; E-mail: akiro{at}hiroshima-u.ac.jp

Received 6 September 2004; revised 21 December 2004; accepted 28 December 2004

Metastatic retinoblastoma of the jaws is very rare. We present a 4-year-old boy with metastatic retinoblastoma that involved both the maxilla and mandible simultaneously. Enhanced CT indicated bone-destructive masses with partially non-enhanced area and enhanced margin in the right maxilla and left mandible. MRI showed well-delineated masses that were isointense on T₁ weighted images and hyperintense on T₂ weighted images. Four weeks after chemotherapy and bone marrow transplantation, the size of lesions remarkably decreased. The patient died 19 months later with extensive tumour metastases despite additional chemotherapy. In this case, the dental crypt of a permanent tooth was considered the potential target through which retinoblastoma metastasized to the jaws.

Keywords: retinoblastoma; maxilla; mandible; metastasis