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Dentomaxillofacial Radiology (2005) 34, 274-278
© 2005 British Institute of Radiology
doi: 10.1259/dmfr/74230043

RESEARCH

Expression of permeability-glycoprotein (P-gp) and uptake of technetium-99m-hexakis-2-methoxy-isobutyl-isonitrile (99Tcm-MIBI) in malignant tumour of the head and neck

T Sato*,1, Y Kawabata1, T Nitta2, Y Saigo3, Y Iwashita1, S Suenaga1, S Hamahira1, H Indo1, Y Morita4, HJ Majima1 and K Sugihara2

1 Field of Oncology, Department of Maxillofacial Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan; 2 Field of Oral and Maxillofacial Rehabilitation, Department of Oral and Maxillofacial Diagnostic and Surgical Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan; 3 Division Clinical Engineering, Kagoshima University Hospital, Kagoshima, Japan; 4 Department of Oral Radiology, Tsurumi University School of Dental Medicine, Tsurumi, Japan

*Correspondence to: Tsuyoshi Sato, Field of Oncology, Department of Maxillofacial Radiology, Kagoshima University Graduate School of Medical and Dental Science, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; E-mail: sato{at}denta.hal.kagoshima-u.ac.jp

Received 12 October 2004; revised 22 February 2005; accepted 15 March 2005

This evaluation was performed with a help of Grant-in-Aid for Science Research (C)(2), No. 13671972 in Japan.

Objectives: The purpose of this study is to estimate the role of permeability-glycoprotein (P-gp) in the technetium-99m-hexakis-2-methoxy-isobutyl-isonitrile (99Tcm-MIBI) scintigraphy.

Methods: 71 patients with squamous cell carcinoma (39 patients with well differentiated, 19 with moderately differentiated and 13 with poorly differentiated tumour) were examined. Eighteen of these patients underwent 99Tcm-MIBI scintigraphy (early and delayed scans). The tumour retention index, obtained from the ratio of the accumulation of the delayed scan to that of the early scan, was divided into three groups. The immunohistochemical evaluation of P-gp expression was performed in all 71 patients. Levels of the P-gp expression were classified into three grades (score 0, 1 and 2). Correlations among the tumour retention index, the P-gp expression and the tumour tissue differentiation were evaluated.

Results: 17 of 18 patients showed a decreasing of the tumour retention index ranging from 0.70 to 0.93 (mean±SD=0.850±0.071). The tumour retention index showed a statistical correlation with the P-gp expression and the tumour tissue differentiation (chi-squared=7.802>7.779, P=0.10 and 16.835>14.860, P=0.005, respectively). Moreover, there was a statistical correlation between the P-gp expression and the tumour tissue differentiation (chi-squared=14.863>14.860, P=0.005).

Conclusion: There is a possibility that the P-gp expression is high in the high-grade malignant tumours and P-gp causes the decrease of tumour retention index.

Keywords: scintigraphy; 99Tcm-MIBI; P-glycoprotein; tumour retention index






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