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Dentomaxillofacial Radiology (2006) 35, 24-29
© 2006 British Institute of Radiology
doi: 10.1259/dmfr/96590988

RESEARCH

Interpretation of scintigraphic findings of oral malignant tumours with a new scanning agent of technetium-99m-hexakis-2-methoxy-isobutyl-isonitrile (Tc-99m-MIBI)

T Sato*,1, Y Kawabata1, Y Saigo2, Y Iwashita1, S Suenaga1, H Indo1, S Hamahira1, K Kawano1, T Nitta3, Y Morita4, HJ Majima1 and K Sugihara3

1 Field of Oncology, Department of Maxillofacial Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan; 2 Division of Clinical Engineering, Kagoshima University Hospital, Kagoshima, Japan; 3 Field of Oral and Maxillofacial Rehabilitation, Department of Oral and Maxillofacial Diagnostic and Surgical Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan; 4 Department of Oral Radiology, Tsurumi University School of Dental Medicine, Tsurumi, Japan

*Correspondence to: Tsuyoshi Sato, Field of Oncology, Department of Maxillofacial Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan; E-mail: sato{at}denta.hal.kagoshima-u.ac.jp

Received 12 October 2004; revised 5 April 2005; accepted 14 June 2005

Objectives: The purpose of this study was to investigate the usefulness of a new scanning agent of technetium-99m-hexakis-2-methoxy-isobutyl-isonitrile (Tc-99m-MIBI) for the diagnosis of malignant tumours of the head and neck.

Methods: Scintigraphy with Tc-99m-MIBI was performed in 19 patients with malignant tumours of the head and neck. Factors of the early and delayed static scans (hot, warm or cold uptake), the early and delayed retention indexes, the blood flow index and the tumour retention index were obtained from Tc-99m-MIBI scintigraphy. Tumour retention indexes were classified into three grades; slightly (>0.9), moderately (0.9–0.8) and severely (0.8>) decreased. Grade of tissue differentiation of tumour (well, moderately or poorly differentiated) and tumour size (T1~T4) were examined using the excised tumour. Scintigraphic indexes and tumour characteristics were compared.

Results: The early static scan and tumour size showed a correlation with the blood flow index. However, the delayed static scan did not show any relationship with blood flow index and tumour size. The tumour retention index had a tendency to decrease in malignant tumours, and showed a significant correlation with the grade of tissue differentiation of the tumour.

Conclusions: The tendency of the tumour retention index to decrease in Tc-99m-MIBI scintigraphy showed the malignancy of tumour and would be useful for the diagnosis of malignant tumours of the head and neck.

Keywords: scintigraphy;; Tc-99m-MIBI;; tumour retention index;; malignant tumour






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