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Acute lymphoblastic leukaemia: an unusual radiological presentation

¹Department of Oral and Dental Science, Division of Restorative Dentistry, Bristol Dental Hospital, UK; ²Department of Oral and Dental Science, Division of Oral Medicine, Pathology and Microbiology, Bristol Dental Hospital, UK

*Correspondence to: Rahat Ali, Department of Oral and Dental Science, Bristol Dental Hospital, Lower Maudlin Street, Bristol, BS1 2LY, UK; E-mail: rahat224{at}hotmail.com

Received 12 March 2008; revised 19 May 2008; accepted 19 May 2008

A 14-year-old female patient attended Bristol Dental Hospital for an oral screening prior to undergoing a bone marrow transplant as treatment for her acute lymphoblastic leukaemia. Maxillofacial radiographs revealed multiple, well-defined, non-corticated radiolucent lesions throughout the vault of her skull and mandible. These radiological features (coupled with the patient's age) would have correlated with a diagnosis of Langerhans cell histiocytosis. However, a previous bone marrow biopsy confirmed that the patient did indeed have acute lymphoblastic leukaemia. The lytic lesions were present throughout her entire skeletal frame and had previously led to episodes of leg and abdominal pain. We feel that this radiological presentation of leukaemia needs to be reported as these features could easily have been confused with other haematological or even malignant conditions.

Keywords: leukaemia, well defined, non-corticated, radiolucent, lesions