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Dentomaxillofacial Radiology (2009) 38, 465-469
© 2009 British Institute of Radiology
doi: 10.1259/dmfr/24350438

RESEARCH

Diagnostic accuracy of microcomputed tomography for osseous abnormalities in the rat temporomandibular joint condyle

S Kameoka1, Y Kuroki2,3, K Honda*,1,4, N Kijima2, K Matsumoto1,4, M Asano5,6, Y Arai1 and T Shirakawa2,3

1Department of Oral and Maxillofacial Radiology, Nihon University School of Dentistry, Tokyo, Japan; 2Department of Pediatric Dentistry, Nihon University School of Dentistry, Tokyo, Japan; 3Division of Oral and Craniomaxillofacial Research, Dental Research Center, Nihon University School of Dentistry, Tokyo, Japan; 4Division of Advanced Dental Treatment, Dental Research Center, Nihon University School of Dentistry, Tokyo, Japan; 5Department of Pathology, Nihon University School of Dentistry, Tokyo, Japan; 6Division of Immunology and Pathobiology, Dental Research Center, Nihon University School of Dentistry, Tokyo, Japan

*Correspondence to: Kazuya Honda, Department of Oral and Maxillofacial Radiology, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8310, Japan; E-mail: honda-k{at}dent.nihon-u.ac.jp

Received 13 June 2007; revised 20 June 2008; accepted 29 August 2008

Objectives: Our aim was to investigate the diagnostic accuracy of in vivo micro-CT for osseous abnormalities of the rat temporomandibular joint (TMJ) condyle, using macroscopic observations as the "gold standard".

Methods: A 30 TMJ arthritis model was prepared by injecting inflammatory complete Freund's adjuvant (CFA) into one side of the TMJ cavities of rats. The TMJ condyles were then imaged using micro-CT. The samples were macroscopically evaluated for osseous abnormalities, including erosions, osteophytes, flattening and concavity. The micro-CT images were independently assessed for abnormalities using the same criteria. Images in three planes were produced using the micro-XYZ technique with the micro-CT equipment.

Results: According to the macroscopic observations, 26 of the 60 rat condyles showed osseous abnormalities. The micro-XYZ images detected abnormalities in 25 of the condyles. The condyle diagnostic accuracy of micro-CT was 0.98, the sensitivity was 0.96 and the specificity was 1.0.

Conclusions: Good diagnostic results were obtained using micro-CT. It is therefore an effective technique for the evaluation of osseous abnormalities in the rat TMJ condyle.

Keywords: microcomputed tomography; osseous abnormalities; temporomandibular joint morphology






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